News
Master projects available!
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- Created on Monday, 04 March 2013 17:05
This spring 2013, seven master projects are available:
Protein engineering towards stabilization of formyl peptide
receptors for structural determination
Stabilization of human aquaporin 10 for structural
determination
Functional and structural studies of aquaporins
Site-directed isotope labeling of an ion channel using
cell-free protein expression
Molecular genetics of hepatic fat accumulation
Probing protein dynamics with two-dimensional infrared
spectroscopy
Please rank the projects you would like to work on and
send a letter of motivation and CV to kristina.hedfalk @
chem.gu.se.
Breakthrough of the year
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- Created on Sunday, 10 February 2013 05:02
One hundred years ago, physicists showed how x-rays ricocheting through a crystal could reveal the crystal's atomic-scale structure. This year, scientists pushed such “x-ray diffraction” nearly to its ultimate limit when, for the first time, they used an x-ray laser to determine the structure of a protein. The advance shows the potential of x-ray lasers to decipher proteins that conventional x-ray sources cannot.
As a Scientific Highlight for 2012, the journal Science has listed the top ten scientific articles published in Science and Nature during the year. Researchers Richard Neutze and Gergely Katona are co-authors of one of the articles, which reports on the potential for identifying new medicines for sleeping sickness using x-ray lasers to investigate the structure of proteins at atomic level.
Weixiao Yuan Wahlgren, Ph.D.
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- Created on Friday, 19 October 2012 11:20
On October 19th, Weixiao Yuan Wahlgren sucessfully defended hes Ph.D. thesis "Structural Insights at Sub-Ångstrom, Medium and Low resolution: Crystallization of Trypsin, Bacterioferritin, Photosynthetic Reaction Center, and Photosynthetic Core Complex". Opponent for the faculty was Prof. Richard Cogdell, Institute of Molecular, Cell and Systems Biology, University of Glasgow. Congratulations to the new doctor of philosophy!
Open PhD position
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- Created on Wednesday, 03 October 2012 15:21
The Westenhoff research group is looking for a PhD student interested in 2D IR femtosecond spectroscopy.
For Science!
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- Created on Thursday, 16 August 2012 07:07
High-resolution protein structure determination by serial femtosecond crystallography.
Boutet S., Lomb L., Williams G.J., Barends T.R., Aquila A., Doak R.B., Weierstall U., DePonte D.P., Steinbrener J., Shoeman R.L., Messerschmidt M., Barty A., White T.A., Kassemeyer S., Kirian R.A., Seibert M.M., Montanez P.A., Kenney C., Herbst R., Hart P., Pines J., Haller G., Gruner S.M., Philipp H.T., Tate M.W., Hromalik M., Koerner L.J., van Bakel N., Morse J., Ghonsalves W., Arnlund D., Bogan M.J., Caleman C., Fromme R., Hampton C.Y., Hunter M.S., Johansson L.C., Katona G., Kupitz C., Liang M., Martin A.V., Nass K., Redecke L., Stellato F., Timneanu N., Wang D., Zatsepin N.A., Schafer D., Defever J., Neutze R., Fromme P., Spence J.C., Chapman H.N., Schlichting I. (2012).
Experimental geometry for SFX at the CXI instrument. Single-pulse diffraction patterns from single crystals flowing in a liquid jet are recorded on a CSPAD at the 120-Hz repetition rate of LCLS.
Kiss and Duelli et al.
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- Created on Friday, 30 March 2012 16:14
Crystal structure of the S100A4–nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism
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B Kiss, A Duelli, L Radnai, KA Kékesi, G Katona, and L Nyitray
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PNAS Early Edition
Schematic model of S100A4-induced NMIIA filament disassembly.The Ca2þ-loaded S100A4 (yellow) binds to NMIIA at the nonhelical tailpiece, partially unwinds the ACD (blue) and sterically blocks myosinmyosin interactions causing filament disassembly.